董永喜，教授，博士生导师。

研究方向为：1）天然产物成药性结构修饰；2）基于靶点的小分子药物发现；3）基于结构的多肽药物研究。

近年来，主持国家自然科学基金，贵州省自然科学基金，贵州省中药现代化项目，贵州省卫生厅科学技术基金等各类项目共10项，以第一作者或通讯作者在Bioorganic Chemistry, Biochemical Pharmacology, Biomedicine & Pharmacotherapy, Bioorganic & Medicinal Chemistry Letters, Medicinal Chemistry Research等SCI杂志发表研究论文20余篇。授权专利2项。

联系方式：dongyx01@163.com

一、主持科研项目（代表性）

1．基于GSK-3β/AChE双重抑制的抗AD杂交分子的设计、合成及作用机制研究，国家自然科学基金，2024.01-2027.12。

2. 川芎嗪灯盏乙素苷元抗脑卒中孪药的研究，国家自然科学基金，2020.01-2023.12。

3. 基于wnt/β-catenin通路的鼠尾草酸抗肿瘤构效关系研究，贵州省自然科学基金，2022.04-2025.03。

二、代表性论著(近三年)

(1) Shaofang Lv, Yaozhen Gong, Hua Guo, Chong Zheng, Jianfang Ye, Lu Zou, Kai Zhu, Haichang Li, Lei Li*, Yongxi Dong*. Multi-omics decoding of Phalloidin hepatotoxicity: network toxicology-guided identification of FoxO/PLD/cAMP signaling targets. Chemico-Biological Interactions, 2026,423, 111843.

(2) Shanhui Zhang, Fuhui Zhao, Changluan Pan, Yajing Wang, Zhangxiang Yang, Jing Yang, Yunniao Meng, Shaofang Lv, Jiayu, Huang, Li Dong^*, Lei Li^*, Yongxi Dong^*. A novel covalent inhibitor alleviates type 2 diabetes mellitus by restraining GSK-3β, Biochemical Pharmacology, 2025, 242, 117205.

(3) Jianwei Xu, Zhangxiang Yang, Fuhui Zhao, Changluan Pan, Jing Yang, Ziyi Zhang, Li Dong^*, Yongxi Dong^*. Design, synthesis, and biological evaluation of novel GSK-3β covalent inhibitors for cancer treatment. Bioorganic Chemistry, 2025, 164, 108856.

(4) Li Dong^*, Tiemei Long, Shanghui Zhang, Yongqing Mao, Mingji Liu, Fuhui Zhao, Zhangxiang Yang, Lei Li, Shi-Wu Chen^*, Shanggao Liao^*, and Yongxi Dong^*. Structure-activity relationship explorations of 2-(isoxazol-5-yl)phenyl-3,4-dihydroxybenzoate derivatives to develop potent Wnt/β-catenin pathway inhibitors for colorectal cancer treatment. Bioorganic Chemistry, 2025, 160, 108433.

(5) Yongxi Dong*; Fang Wang; Jinlan Wen; Yongqing Mao; hanhui Zhang; Tiemei Long; Zhangxiang Yang; Lei Li; Jiquan Zhang; Li Dong; Gang Liu*; Jianwei Xu*; Synthesis and bioevaluation of Scutellarein-Tertramethylpyrazine hybrid molecules for the treatment of ischemic stroke, Bioorganic Chemistry, 2024, 142, 106978.

(6) Li Dong*; Shanhui Zhang; Lina Chen; Jun Lu; Fuhui Zhao; Tiemei Long; Jinlan Wen; Jiayu Huang; Yuanhu Mao; Zhengfang Qi; Jiquan Zhang; Lei Li*; Yongxi Dong*. In vivo anti-hyperuricemia and anti-gouty arthritis effects of the ethanol extract from Amomumvillosum Lour., Biomedicine & Pharmacotherapy. 2023, 161, 114532.

(7) Zheng, Chong; Lv, Shaofang; Ye, Jianfang; Zou, Lu; Zhu, Kai; Li, Haichang; Dong, Yongxi*; Li, Lei*. Metabolomic Insights into the Mechanisms of Ganoderic Acid: Protection against α-Amanitin-Induced Liver Injury. Metabolites, 2023, 13, 1164.

(8) Yongxi Dong*; Jun Lu; Shanhui Zhang; Lina Chen; Jinlan Wen; Fang Wang; Yongqing Mao; Lei Li; Jiquan Zhang; Shanggao Liao*; Li Dong*. Design, synthesis and bioevaluation of 1,2,4- thiadiazolidine-3,5-dione derivatives as potential GSK-3β inhibitors for the treatment of Alzheimer’s disease, Bioorganic Chemistry. 2023, 134, 106446.

三、授权专利

(1) 董永喜; 董莉; 廖尚高; 刘明吉; 何迅; 杨小生; 毛远湖; 许建炜 ; 一种治疗缺血性脑卒中孪药及其 制备方法, 2021-7-9, 中国, ZL 201910538346.x (专利)

(2) 董永喜; 董莉; 刘明吉; 吴淑霞; 毛永清; 廖尚高; 何迅; 张吉泉; 周孟; 关焕玉; 徐国波; 杨小生; 一种2-(异噁唑-5-基)苯基-3,4-二羟基苯甲酸酯及其衍生物及合成方法和应用, 2023-10-20, 中国, ZL 202210520035.2